Olga Kovbasnjuk
Title: No-redundant role of human epithelial Wnt2B and Desert Hedgehog in Regeneration of Human Colonoids following injury by Enterohemorrhagic E. coli (EHEC) cytotoxin EspP.
Biography
Olga Kovbasnjuk has her expertise
in intestinal physiology and pathophysiology, with recent emphasis
on the role of intestinal stem cells in tissue regeneration after pathogen-induced injury.
She has adopted the stem cell derived organoid model and transformed the 3D
structures into Matrigel-free intestinal epithelial layers with access to the
luminal and serosal surfaces, thus providing an advantage in studying gut
luminal commensals, microbial infectious agents and testing strategies for
luminally-administered pharmacologic agents to stimulate tissue regeneration
post-injury
