Dr. Murkamilov Ilkhom Torobekovich is the chairman Board "Society of specialists in chronic kidney disease Kyrgyzstan". Candidate of Medical Sciences, acting Associate Professor of department faculty therapy Kyrgyz State Medical Academy named after I.K. Ahunbaev. Creator of over 100 scientific publications in clinical nephrology, cardiology and internal diseases. Co-author of monograph on intestinal human microbiota. Currently studying prevalence, progression mechanisms of diabetic and non-diabetic etiology of chronic kidney disease (CKD) among residents of the Kyrgyz Republic, cardiovascular and cerebral complications in patients with CKD, epigenetic mechanisms of human aging, gender and age features of kidney function in habitants of the Kyrgyz Republic. Dr. Murkamilov I.T. is vice chairman of the community young doctors and healthcare providers. Since 2017 included the composition of the editorial board of leading peer-reviewed journals.
Aims of the study. Studying the prevalence of risk factors for progression chronic kidney disease according to a survey of a representative sample of habitants in the Kyrgyz Republic.
Materials and methods. Surveyed 1403 people with established diagnosis of chronic kidney disease (CKD): 871 (62.1%) men and 532 (37.9%) women, the average age is 42.2±14.8 years. The present study included clinical and laboratory information of patients examined by nephrologists in the city Bishkek. At the first stage, the address of the patient’s, anamnesis, information about taken drugs, clinical examination data at the time of examination, double measurement of blood pressure and heart rate reduced body weight. All examined individuals analyzed the hemoglobin content, the number of red blood cells in the peripheral blood and the value of protein excretion in solitary urine. Biochemical analysis included evaluation concentrations of creatinin, total cholesterol, uric acid and blood glucose. Glomerular filtration rate (GFR) was calculated using the formula CKD-EPI (Chronic Epidemiological collaboration for kidney disease). CKD was diagnosed according to K/DOQI (Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification and Stratification, 2002).
Results. Prevalence of signs of nephropathy with safe (optimal) GFR in a representative sample of the Kyrgyz Republic population made up 23.8% (334). Signs of nephropathy and a slight decrease in GFR were noted in 244 patients (17.3%), a moderate decrease in GFR - in 309 (22.0%) examined patients. Hard degree of GFR was found in 172 patients (12.2%), and 344 (24.5%) individuals had signs of end-stage renal failure. Risk factors for the progression of CKD were considered body mass deficiency, obesity, arterial hypertension (AH), hyperglycemia, hyperuricemia, anemia, proteinuria of the nephrotic level. Underweight was detected in 54 (3.8%) patients, obesity in 409 (29.1%), AH in 748 (53.3%), hyperglycemia in 613 (43.6%), hyperuricemia in 571 (40.6%), anemiain 490 (34.9%), and cases - nephrotic proteinuria 403 (28.7%).
Conclusion. Most common risk factor for CKD progression in Kyrgyz Republic habitants was obesity, hypertension and hyperglycemia.