Edward H. Abraham

Title: Cystic fibrosis improves COVID-19 survival and provides clues for treatment of SARS-CoV-2

Biography

Edward H. Abraham graduated from Harvard University with a college major in engineering, applied physics and chemistry. He was then accepted into the first class of the Harvard - MIT graduate program in Health Sciences and Technology and subsequently received his MD from Harvard Medical School. During his medical school training, he gained valuable research experience working in the laboratories of Professors Judah Folkman, Claude Lechene and Nobel Laureate Konrad Bloch. During his internship, residency and fellowship in pediatrics at Boston Children’s Hospital Medical Center, he worked directly with Professor Harry Shwachman and in the laboratory of Professor Jan Breslow focusing on cystic fibrosis (CF). He extended his CF studies with a subsequent post-doctoral research clinical investigator award from NIH. His work focused on membrane biochemistry in the laboratory of Professor Guido Guidotti at Harvard University. During these investigations, he discovered and investigated the functions of ATP releasing pathways using biochemical and electrophysiological (patch-clamp) assays. He developed luciferase assays for precise measurement and imaging of extracellular ATP clouds. Resultant publications resulted in the receipt of an unexpected supportive letter of encouragement from Professor Geoffrey Burnstock. This was followed by an invitation to lecture at the Purine Club. A long-term friendship with Geoffrey Burnstock followed. Dr. Abraham then completed a radiation oncology residency at Massachusetts General Hospital, Boston and a subsequent Senior Investigator position with Dr. Paul Okunieff at the National Cancer Institute (NCI) where the role of extracellular ATP in cancer treatment was investigated. While at NIH, Dr. Abraham participated in collaborations with Dr. Michail Sitkovsky’s group considering the relative roles of extracellular ATP and extracellular adenosine. He subsequently assumed directorship of the Radiation Oncology Translational Research laboratory at Dartmouth Medical School in Hanover, NH. At Dartmouth he ran clinical trials testing the effects of ATP intravenous infusions on patients with stage IV cancers. Dr. Abraham continues to investigate and apply roles of extracellular ATP in patients with cancer through the integration of administered ATP and the use of photobiomodulation (PBM), hyperthermia, and ionizing radiation therapy

Research Interest


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