Jinbo Deng

Title: Mouse Induced Pluripotent Stem Cells-Derived Alzheimer’s Disease Cerebral Organoid Culture and Neural Differentiation Disorders


Jinbo Deng, Ph. D. a professor of Scientific and Technical Institute of Population and Family Planning, Henan Province, China. He has expertise in developmental neurobiology. Using 3D-culture technique, his group has cultured AD (Alzheimer’s disease) cerebral organoids with APP and PSEN1 mutations. These AD cerebral organoids show some AD pathological disorders, such as, A? and p-Tau overexpressions, increases of astrocytes and glutamatergic excitatory neurons and decrease of GABAergic interneurons. The model may provide us a novel insight to understand the pathogenesis of AD.

Research Interest

Alzheimer’s disease

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