Molecular Genetics and Biology of Dementia

Molecular biological research has significantly enhanced our understanding of Alzheimer's dementia's pathophysiological basis. In our understanding of dementia genetics and molecular biology, considerable progress has been made. To date, certain genetic risk factors have been identified, but only a small percentage of AD cases can be explained by specific gene mutations. Genes may be related to disease in two ways: through autosomal-dominant mutations, in themselves sufficient to cause the disease alternatively, gene variations (polymorphisms) may indirectly increase disease risk without being sufficient in them to cause the disorder.