Alzheimer's is caused by the death of brain cells. It is a neurological disorder in which brain cell death leads to a loss of memory and a cognitive decline. The total brain shrinks in Alzheimer's, nerve cells and tissue connections that cannot be seen or tested in the living brain affected by Alzheimer's disease, post - mortem / autopsy always shows small inclusions in nerve tissues called plaques and tangles. Plaques are found between dying cells in the brain-from the development of the beta-amyloid (amyloid plaques) protein. In brain neurons, the tangles exist from the disintegration of the second protein called tau.
Worldwide, nearly 44 million people suffered from dementia or related disorders in 2015, past results showed that 35,66 million people lived with dementia worldwide in 2010, with numbers expected to almost double every twenty years, to 65,7 million in 2030 and 115,4 million in 2050. In 2010, 58% of the population with dementia lived in countries with low or moderate incomes, which is expected to increase to 63% by 2030 and 71% by 2050. This condition is anticipated to double by 2030 and quite triple by 2050 to 115 million.
In this track we can discuss:
Neurological changes in brain, Amyloid protein, Genetic associations and susceptibility genes, Role of Apo lipoprotein E, Brain trauma, Metabolic syndrome and Alzheimer’s disease, Protein misfolding, aggregation and toxicity, Disease-causing mutations, Epidemiology and prevalence, Histone modification, DNA methylation, Alzheimer’s disease prevention.
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