Ivanela Kondova

Title: Biobank at biomedical primate research Centre, the Netherlands: attractive alternative source for scientific research
Time: 10:00 - 10:45

Biography

Dr. Ivanela Kondova is a Veterinary Anatomic Pathologist and Head of Division of Pathology and Microbiology at Biomedical Primate Research Center in Netherlands. She is actively involved in clinical and translational research and also in scientific projects for global pharmaceutical industry, World Health Organization and different academic institutions. She was trained as a Veterinary pathologist at the New England Primate Research Center - Harvard Medical School in Massachusetts, United States. She gained extensive experience in the area of infectious diseases while she was working at Tufts Veterinary University, Infectious Disease Department, Massachusetts, United States. She is the creator and the manager of the biggest nonhuman primate Tissue Bank in Europe. She has published more than 70 scientific papers in peer-reviewed journals.

Research Interest


Abstract

Tissues and genetic material collected from non-human primates (NHP) represent a valuable resource in biomedical research. Obtaining this type of material is limited, time demanding and needs high expertise. As pressure grows for reduction of numbers of animals used in research, the Biobanks are becoming an attractive alternative source for testing scientific ideas, pathophysiological mechanisms and testing new vaccines and biologicals before proceeding to preclinical studies.

The BPRC’s Primate Biobank is the biggest nonhuman primate Biobank in Europe and it is based on the principals of the 3Rs: refinement, reduction and replacement (3Rs). The aim of the Biobank is to provide rare and valuable specimens for internal and external scientists who can use the material for biomedical research as well as for conservation studies.

BPRC’s nonhuman primate biobank consists of:

1. Tissue bank: organs, tissues and cell lines. Samples are collected from the following primate species: Rhesus macaques (Macaca mulatta), Long-tail macaque (Macaca fascicularis), Common marmoset (Callithrix jacchus) and from endangered species such as great apes - Common chimpanzee (Pan troglodytes) and Orangutan (Pongo Borneo) Organs without morphological alterations from clinically healthy retired animals and tissues with experimentally induced or spontaneously developed pathological conditions are available. The organ- and tissue- collections include snap frozen tissue samples stored at -80 C, samples fixed in 10 % neutral buffered formalin (NBF), formalin fixed paraffin embedded (FFPE) tissues and cell lines frozen and stored in liquid nitrogen. Part of the tissue bank are the catalogued frozen tissue collections such as: a/ brain samples from different brain regions of young and aged NHPs and apes; b/ reproductive organs from different NHP’ genders; c/ bone collections and d/ lymphoid organs.

2. Serum and Gene bank: Serum and plasma samples are available. DNA, RNA, cDNA samples are adequately stored at +4, -20 or -80 °C.