Dr. Natalia Shestakova
Title: The New Technology for Creating Complex Therapy. Psychotropic Drugs for the Management of Neuropathic Pain and Itch.
Biography
Dr. Natalia Shestakova research focuses on the
study of neuropathic pain and itching using various procedural approaches.
Using molecular modeling techniques, she has developed a technology for
preliminary screening of three-dimensional structural selection among
psychotropics the effective drugs for the treatment of neuropathic pain and
itching syndromes. To understand the mechanisms for the relief of neuropathic
pain, she studies the molecular targets of the glutamatergic system (NMDA
receptors and calcium exchanger sodium) using electrophysiological methods and
molecular modeling. As a result, 9 drugs were selected as potentially effective
drugs. Subsequent clinical trials have confirmed their analgesic and
antipruritic ability in contrast to drugs selected as inert. Together with doctors
of Pavlova State Medical University, the complex therapy was developed for
patients with end-stage renal disease in chronic hemodialysis and patients with
insulin-dependent diabetes for personalized treatment of pain and itching
syndromes without increasing drug consumption
Research Interest
neuropathic pain and itching; psychotropics,
molecular targets and mechanisms
